Reaction Dynamics of ATP Hydrolysis Catalyzed by P-Glycoprotein
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چکیده
منابع مشابه
Reaction Dynamics of ATP Hydrolysis Catalyzed by P-Glycoprotein
P-glycoprotein (P-gp) is a member of the ABC transporter family that confers drug resistance to many tumors by catalyzing their efflux, and it is a major component of drug-drug interactions. P-gp couples drug efflux with ATP hydrolysis by coordinating conformational changes in the drug binding sites with the hydrolysis of ATP and release of ADP. To understand the relative rates of the chemical ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2014
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi401280v